GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs7200543 | 1 | rs6498541 | chr16:15140657 | NTAN1 | chr16:15131717-15149833:- | 0.14 | 4.18 | 3.46E-5 | Metabolic traits;Glycerophospholipid levels |
| THCA | cis | rs7200543 | 1 | rs6498541 | chr16:15140657 | PDXDC1 | chr16:15068599-15233195:+ | 0.32 | 7.48 | 3.62E-13 | Metabolic traits;Glycerophospholipid levels |
| THCA | cis | rs6499255 | 1 | rs6499253 | chr16:69802672 | COG4 | chr16:70514473-70557457:- | -0.19 | -3.84 | 0.000139 | IgE levels |
| THCA | cis | rs6499255 | 1 | rs6499255 | chr16:69830328 | COG4 | chr16:70514473-70557457:- | -0.2 | -4.18 | 3.42E-5 | IgE levels |
| THCA | cis | rs62055045 | 1 | rs6499508 | chr16:71396290 | CALB2 | chr16:71392626-71424339:+ | 0.41 | 5.57 | 4.2E-8 | Schizophrenia |
| THCA | cis | rs62055045 | 1 | rs6499508 | chr16:71396290 | HPR | chr16:72097125-72111144:+ | -0.32 | -4.27 | 2.33E-5 | Schizophrenia |
| THCA | cis | rs12709013 | 1 | rs6499983 | chr16:58843909 | GOT2 | chr16:58741035-58768246:- | -0.26 | -7.32 | 1.05E-12 | Blood metabolite ratios |
| THCA | cis | rs12709013 | 1 | rs6499983 | chr16:58843909 | SLC38A7 | chr16:58700298-58718674:- | -0.14 | -4.98 | 8.9E-7 | Blood metabolite ratios |
| THCA | cis | rs6500602 | 1 | rs6500602 | chr16:4497451 | C16orf5 | chr16:4560679-4588816:- | 0.24 | 6.22 | 1.07E-9 | Schizophrenia |
| THCA | cis | rs6502050 | 1 | rs6502050 | chr17:80058236 | DCXR | chr17:79993758-79995573:- | 0.13 | 3.77 | 0.000183 | Life satisfaction |
| THCA | cis | rs4924935 | 1 | rs6502674 | chr17:18776897 | FAM18B | chr17:18684582-18710026:+ | -0.32 | -7.37 | 7.4E-13 | Pancreatic cancer |
| THCA | cis | rs9914544 | 1 | rs6502677 | chr17:18803658 | FAM18B | chr17:18684582-18710026:+ | -0.42 | -10.68 | 5.05E-24 | Educational attainment (years of education) |
| THCA | cis | rs9914544 | 1 | rs6502677 | chr17:18803658 | FBXW10 | chr17:18647326-18682661:+ | -0.23 | -4.97 | 9.44E-7 | Educational attainment (years of education) |
| THCA | cis | rs8078723 | 1 | rs6503530 | chr17:38161823 | GSDMA | chr17:38119226-38134019:+ | -0.31 | -7.25 | 1.71E-12 | Neutrophil count;White blood cell count;C-reactive protein and white blood cell count |
| THCA | cis | rs11871801 | 1 | rs6503703 | chr17:40592207 | HSD17B1 | chr17:40703984-40707224:+ | -0.12 | -3.36 | 0.000843 | Crohn's disease |